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Vysio

Wearable hemodynamic monitoring, from the bedside to the EMR.

Overview

Vysio is the end-to-end software platform behind a wearable hemodynamic monitor. We built every layer: a Bluetooth gateway that streams readings off the device, a real-time nurse-station dashboard, a FHIR R4 canonical store with a custom code system for the device's biomarkers, event-driven orchestration, and an HL7v2 translation engine that delivers results into any hospital EMR. The whole stack runs as a hardened, self-hosted deployment with secrets management and zero-trust networking.

What you get

  • ✓BLE 5.0 device gateway (Python / Bleak) with resilient retry and backoff
  • ✓Real-time nurse station (Next.js, Server-Sent Events) with tiered clinical alerting
  • ✓HAPI FHIR R4 canonical store with a custom Vysio CodeSystem for StO₂ and SFI
  • ✓Event-driven FHIR Subscriptions orchestrated through n8n
  • ✓Mirth Connect FHIR ↔ HL7v2 ORU^R01 translation for any EMR
  • ✓Epic, Oracle Health (Cerner), and universal HL7v2 EMR integration
  • ✓SMART on FHIR (OAuth 2.0) and remote-patient-monitoring billing codes (99453–99458)
  • ✓Hardened cloud: nginx/TLS, HashiCorp Vault, Tailscale + UFW on AWS

How it's built

Vysio moves a reading from the wearable to the chart through four layers — device, gateway, middleware, and EMR. We engineered all of them.

1

Device & Bluetooth

  • Vysio wearable: near-infrared spectroscopy (VCSEL 850 nm + 660/740 nm LEDs)
  • Measures hemoglobin (HbT), tissue oxygen saturation (StO₂), and speckle flow index (SFI) every 15 minutes
  • BLE 5.0 (ANNA-B412) streamed by a Python gateway that parses readings and forwards them over HTTPS with key auth and exponential-backoff retry
2

Nurse station (edge)

  • Real-time Next.js 16 / React 19 dashboard with a live multi-patient grid over Server-Sent Events
  • Tiered clinical alerting — stable, advisory, warning, emergency — with trend charts
  • Writes FHIR Observations and connects to the EMR over OAuth 2.0
3

Middleware & cloud

  • nginx reverse proxy terminating TLS and routing /fhir, /n8n, and /mirth
  • HAPI FHIR R4 canonical store (PostgreSQL) with a custom Vysio CodeSystem and REST-hook Subscriptions
  • n8n orchestration triggered by FHIR Subscription webhooks
  • Mirth Connect translating FHIR to HL7v2 ORU^R01 (MSH/PID/PV1/OBR/OBX) with reference ranges and abnormal flags
  • HashiCorp Vault for secrets; Tailscale (WireGuard) + UFW for zero-trust access on AWS EC2
4

EMR integration

  • Epic: FHIR R4 Observation write-back, flowsheet rows, Best Practice Alerts + InBasket, and RPM billing (CPT 99453–99458) via SMART on FHIR
  • Oracle Health (Cerner): CareAware and HL7v2 via Bridges
  • Other EMRs (Meditech, Allscripts…): universal HL7v2 ORU^R01 over MLLP
Vysio EMR integration architecture — device, gateway, middleware/cloud, and EMR layers
Vysio EMR integration architecture — device, gateway, middleware/cloud, and EMR layers

Built with

  • BLE 5.0
  • Python
  • Bleak
  • Next.js 16
  • React 19
  • HAPI FHIR R4
  • Mirth Connect
  • n8n
  • HL7v2
  • SMART on FHIR
  • HashiCorp Vault
  • nginx
  • PostgreSQL
  • Docker
  • AWS EC2
  • Tailscale

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